We have developed high throughput genome wide CRISPR/Cas loss-of-function approaches to characterize key genes that regulate fundamental cancer processes, including primary tumor growth, tumor metastasis, cancer stemness and resistance to chemotherapy, using pre-clinical mice models. Using these genome-wide forward-genetics approaches, we will extend the scope of our studies and address long-standing challenging questions related to the breast cancer cell origin (i.e. identify specific genetic changes driving malignant transformation of normal cells and tumor development).
New study paves the way to novel treatment for Triple Negative Breast Cancer
