Research Topics

Breast Cancers, TGFβ, Human Cutaneous Melanoma, CRISPR/Cas, MicroRNAs, Preclinical Xenograft, Drug Development

Cancer Stem Cells

Cancer Stem Cells

Self-renewalmetastasischemoresistance

Breast cancer is the most frequently diagnosed malignancy in women and the major cause of patient death is due to invasiveness and dissemination of the tumor to distant secondary sites. TGFβ signaling plays a major role in mediating these tumorigenic events and work from our laboratory has contributed to unravelling the complex oncogenic role of TGFβ. We made inroads into understanding cancer stem…

Keep Reading →
MicroRNAs in Cancer

MicroRNAs in Cancer

miRNAsCancerCRISPR/Cas9

In the last two decades since the discovery of the first microRNA, these short, non-coding molecules have become attractive tools and targets for novel therapeutics against many diseases including cancer. We have identified multiple TGFβ-mediated microRNAs, for example miR-181, miR-584 and miR-30, that regulate tumor suppression and progression. We efficiently reduced primary tumor growth in vivo…

Keep Reading →
Drug Design & Development

Drug Design & Development

CDK InhibitorsDrug ResistanceCancer Stem Cells

Breast cancer is the most diagnosed cancer and the second leading cause of mortality. Triple-negative breast cancer (TNBC) is characterized by the absence of receptors for estrogen and progesterone as well as lack of HER-2 gene. These tumors are enriched in cancer stems cells and exhibit resistance to most treatments and chemotherapy. TNBC is more prevalent in younger females and accounts for…

Keep Reading →
TGFβ Signaling Pathways

TGFβ Signaling Pathways

Dual roles of TGFβ in cancer

Our various projects are based on the dual role of transforming growth factor beta (TGFβ) in cancer. TGFβ exerts tumour suppressive effects in normal cells and in early carcinomas, whereas in advanced cancer it exerts pro-migratory and pro-invasive effects. Therefore, we have developed two lines of research: 1) defining the tumour suppressive role of TGFβ – how this growth factor inhibits cell…

Keep Reading →
Genome CRISPR/Cas loss-of-function screen

Genome CRISPR/Cas loss-of-function screen

CRISPR/Cas9GenesTumor development

We have developed high throughput genome wide CRISPR/Cas loss-of-function approaches to characterize key genes that regulate fundamental cancer processes, including primary tumor growth, tumor metastasis, cancer stemness and resistance to chemotherapy, using pre-clinical mice models. Using these genome-wide forward-genetics approaches, we will extend the scope of our studies and address long…

Keep Reading →